SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.

Bibliographic Details
Main Authors:	Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp, Kristijan Ramadan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11095-y

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spelling	doaj-21ed31bb8358406db2dcfaaf5eadcf042021-05-11T11:33:12ZengNature Publishing GroupNature Communications2041-17232019-07-0110111810.1038/s41467-019-11095-ySPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replicationSwagata Halder0Ignacio Torrecilla1Martin D. Burkhalter2Marta Popović3John Fielden4Bruno Vaz5Judith Oehler6Domenic Pilger7Davor Lessel8Katherine Wiseman9Abhay Narayan Singh10Iolanda Vendrell11Roman Fischer12Melanie Philipp13Kristijan Ramadan14Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordInstitute of Biochemistry and Molecular Biology, Ulm UniversityCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordInstitute of Human Genetics, University Medical Center Hamburg-EppendorfCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordTDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of OxfordInstitute of Biochemistry and Molecular Biology, Ulm UniversityCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.https://doi.org/10.1038/s41467-019-11095-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan
spellingShingle	Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication Nature Communications
author_facet	Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan
author_sort	Swagata Halder
title	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_short	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_full	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_fullStr	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_full_unstemmed	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_sort	sprtn protease and checkpoint kinase 1 cross-activation loop safeguards dna replication
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.
url	https://doi.org/10.1038/s41467-019-11095-y
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SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

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