Increased Cytoplasmic CD138 Expression Is Associated with Aggressive Characteristics in Prostate Cancer and Is an Independent Predictor for Biochemical Recurrence

Increased Cytoplasmic CD138 Expression Is Associated with Aggressive Characteristics in Prostate Cancer and Is an Independent Predictor for Biochemical Recurrence

Syndecan-1 (CD138) is a transmembrane proteoglycan expressed in various normal and malignant tissues. It is of interest due to a possible prognostic effect in tumors and its role as a target for the antibody-drug conjugate indatuximab ravtansine. Here, we analyzed 17,747 prostate cancers by immunohi...

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Bibliographic Details
Main Authors: Simon Kind, Martina Kluth, Claudia Hube-Magg, Katharina Möller, Georgia Makrypidi-Fraune, Florian Lutz, Maximilian Lennartz, Sebastian Dwertmann Rico, Thorsten Schlomm, Hans Heinzer, Doris Höflmayer, Sören Weidemann, Ria Uhlig, Hartwig Huland, Markus Graefen, Christian Bernreuther, Maria Christina Tsourlakis, Sarah Minner, David Dum, Andrea Hinsch, Andreas M. Lübke, Ronald Simon, Guido Sauter, Andreas Marx, Adam Polonski
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/5845374

Internet

http://dx.doi.org/10.1155/2020/5845374

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