The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.
A variety of circumstantial evidence from humans has implicated the B cell antigen receptor (BCR) in the genesis of B cell lymphomas. We generated mouse models designed to test this possibility directly, and we found that both the constitutive and antigen-stimulated state of a clonal BCR affected th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-06-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2435152?pdf=render |