Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis

Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis

A shared genetic pre-disposition, chronic inflammation, and treatment with similar biologics between Rheumatoid arthritis (RA) and Crohn's disease (CD) have intrigued us to investigate whether the two disorders share trigger association or possible causation. We hypothesized earlier that Single...

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Bibliographic Details
Main Authors: Robert C. Sharp, Shazia A. Beg, Saleh A. Naser
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
rheumatoid arthritis
PTPN2
PTPN22
PTPN2/22
mycobacteria
SNPs
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00011/full

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http://journal.frontiersin.org/article/10.3389/fcimb.2018.00011/full

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