sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation

sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation

The adaptive immune system generates an incredible diversity of antigen receptors for B and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these receptors arise by a complex recombination process followed by a series of productivity-based filters, as well as affinity matura...

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Bibliographic Details
Main Authors: Branden J. Olson, Pejvak Moghimi, Chaim A. Schramm, Anna Obraztsova, Duncan Ralph, Jason A. Vander Heiden, Mikhail Shugay, Adrian J. Shepherd, William Lees, Frederick A. Matsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
repertoire comparison
model validation
rep-seq
B cell receptor
T cell receptor
summary statistics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02533/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02533/full

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