Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-I editing of the primary (pri-)microRNAs in vascular...

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Bibliographic Details
Main Authors: Reginald V.C.T. van der Kwast, Laura Parma, M. Leontien van der Bent, Eva van Ingen, Fabiana Baganha, Hendrika A.B. Peters, Eveline A.C. Goossens, Karin H. Simons, Meindert Palmen, Margreet R. de Vries, Paul H.A. Quax, A. Yaël Nossent
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
microRNA
A-to-I editing
ischemia
peripheral artery disease
angiogenesis
target gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302092

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http://www.sciencedirect.com/science/article/pii/S2162253120302092

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