Long-Term Effects of Maternal Low-Protein Diet and Post-weaning High-Fat Feeding on Glucose Metabolism and Hypothalamic POMC Promoter Methylation in Offspring Mice

Long-Term Effects of Maternal Low-Protein Diet and Post-weaning High-Fat Feeding on Glucose Metabolism and Hypothalamic POMC Promoter Methylation in Offspring Mice

Substantial evidence indicated that maternal malnutrition could increase the susceptibility to obesity, insulin resistance, and type 2 diabetes in adulthood. It is increasingly apparent that the brain, especially the hypothalamus, plays a critical role in glucose homeostasis. However, little informa...

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Bibliographic Details
Main Authors: Jia Zheng, Ling Zhang, Jiayi Liu, Yanli Li, Junqing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Nutrition
Subjects:
glucose metabolism
hypothalamus
DNA methylation
offspring
maternal low-protein diet
post-weaning high-fat feeding
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.657848/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.657848/full

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