Widespread increases in malondialdehyde immunoreactivity in dopamine-rich and dopamine-poor regions of rat brain following multiple, high doses of methamphetamine.

Widespread increases in malondialdehyde immunoreactivity in dopamine-rich and dopamine-poor regions of rat brain following multiple, high doses of methamphetamine.

Treatment with multiple high doses of methamphetamine (METH) can induce oxidative damage, including dopamine (DA)-mediated reactive oxygen species (ROS) formation, which may contribute to the neurotoxic damage of monoamine neurons and long-term depletion of DA in the caudate putamen (CPu) and substa...

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Bibliographic Details
Main Authors: Kristen Ashley eHorner, Yamiece E. Gilbert, Susan D. Cline
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Systems Neuroscience
Subjects:
Dopamine
Lipid Peroxidation
Substantia Nigra
Striatum
Neurotoxicity
psychostimulant
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00027/full

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