Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses

Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses

Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against some viral infections. Immune modulation of CD8+ T cell responses during IFNα therapy is believed to play a pivotal role in promoting viral clearance. However, these clinical studies primarily focused on I...

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Bibliographic Details
Main Authors: Julia Dickow, Sandra Francois, Rouven-Luca Kaiserling, Anna Malyshkina, Ingo Drexler, Astrid Maria Westendorf, Karl Sebastian Lang, Mario L. Santiago, Ulf Dittmer, Kathrin Sutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
IFNα subtypes
antigen-specific CD8+ T cell responses
DCs
IFNAR
cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02255/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02255/full

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