Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors – Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP

Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors – Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP

IntroductionCardiovascular dysfunction is a potentially lethal complication of hypothermia. Due to a knowledge gap, pharmacological interventions are not recommended at core temperatures below 30°C. Yet, further cooling is induced in surgical procedures and survival of accidental hypothermia is repo...

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Bibliographic Details
Main Authors: Anders L. Selli, Adrina K. Kuzmiszyn, Natalia Smaglyukova, Timofei V. Kondratiev, Ole-Martin Fuskevåg, Roy A. Lyså, Aina W. Ravna, Torkjel Tveita, Georg Sager, Erik S. Dietrichs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
hypothermia
PDE5-inhibitors
cyclic AMP
cyclic GMP
afterload reduction
cardiovascular dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.695779/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.695779/full

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