Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progeni...

Full description

Bibliographic Details
Main Authors: Xinde Zheng, Leah Boyer, Mingji Jin, Jerome Mertens, Yongsung Kim, Li Ma, Michael Hamm, Fred H Gage, Tony Hunter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
glycolysis
neuronal differentiation
stem cell
LDHA
metabolism
tricarboxylic acid cycle
Online Access:https://elifesciences.org/articles/13374

Internet

https://elifesciences.org/articles/13374

Similar Items