Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo

Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo

Sulfated glycosaminoglycans (sGAG) show interaction with biological mediator proteins. Although collagen-based biomaterials are widely used in clinics, their combination with high-sulfated hyaluronan (sHA3) is unexplored. This study aims to functionalize a collagen-based scaffold (Mucograft®) with s...

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Bibliographic Details
Main Authors: Sarah Al-Maawi, Sandra Rother, Norbert Halfter, Karen M. Fiebig, Juliane Moritz, Stephanie Moeller, Matthias Schnabelrauch, Charles James Kirkpatrick, Robert Sader, Hans-Peter Wiesmann, Dieter Scharnweber, Vera Hintze, Shahram Ghanaati
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-02-01
Series:Bioactive Materials
Subjects:
Sulfated hyaluronan
Collagen
Wound healing
Cellular reaction
Multinucleated giant cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21002929

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X21002929

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