NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses. Many pathological conditions are linked to imbalances in redox homeostasis, i...

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Bibliographic Details
Main Authors: Matthew Dodson, Raul Castro-Portuguez, Donna D. Zhang
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718310267