NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses. Many pathological conditions are linked to imbalances in redox homeostasis, i...
Main Authors: | Matthew Dodson, Raul Castro-Portuguez, Donna D. Zhang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-05-01
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Series: | Redox Biology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231718310267 |
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