Chiral donor–acceptor azetines as powerful reactants for synthesis of amino acid derivatives
Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines, which react with nucleophiles yielding amino ac...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-13326-8 |