Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds wer...

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Bibliographic Details
Main Authors: Haibing He, Yinghua Ge, Hong Dai, Song Cui, Fei Ye, Jia Jin, Yujun Shi
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
protein tyrosine phosphatase 1B (PTP1B)
lithocholic acid
stilbene
inhibitor
Online Access:http://www.mdpi.com/1420-3049/21/12/1722

Internet

http://www.mdpi.com/1420-3049/21/12/1722

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