Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system...

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Bibliographic Details
Main Authors: Nadja Kern, Rui Dong, Shawn M Douglas, Ronald D Vale, Meghan A Morrissey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
Phagocytosis
Antibody
DNA origami
immunotherapy
Fc Receptor
synthetic biology
Online Access:https://elifesciences.org/articles/68311

Internet

https://elifesciences.org/articles/68311

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