Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography
We used inclined lithography to fabricate a pneumatic microvalve for tall microchannels such as those used to convey large cells. The pneumatic microvalve consists of three layers. The upper layer is the actual liquid microchannel, which has a parallelogram-shaped cross section of width 500 μm, heig...
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doaj-2237a73dfd2c4f25858f5f45dd37637d2020-11-24T23:21:54ZengMDPI AGMicromachines2072-666X2016-12-0171222410.3390/mi7120224mi7120224Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined LithographyMaho Kaminaga0Tadashi Ishida1Toru Omata2Department of Mechanical Engineering, School of Engineering, Tokyo Institute of Technology, Yokohama 226-8502, Kanagawa, JapanDepartment of Mechanical Engineering, School of Engineering, Tokyo Institute of Technology, Yokohama 226-8502, Kanagawa, JapanDepartment of Mechanical Engineering, School of Engineering, Tokyo Institute of Technology, Yokohama 226-8502, Kanagawa, JapanWe used inclined lithography to fabricate a pneumatic microvalve for tall microchannels such as those used to convey large cells. The pneumatic microvalve consists of three layers. The upper layer is the actual liquid microchannel, which has a parallelogram-shaped cross section of width 500 μm, height 100 μm, and an acute angle of 53.6°. The lower layer is a pneumatic microchannel that functions as an actuator, and the middle layer is a thin polydimethylsiloxane membrane between the upper and lower layers. The operation of the pneumatic microchannel actuator causes the thin membrane to bend, resulting in the bending of the liquid microchannel and its closure. It was confirmed that the closure of the liquid microchannel completely stopped the flow of the HeLa cell suspension that was used to demonstrate the operation of the microvalve. The HeLa cells that passed through the microchannel were also observed to retain their proliferation and morphological properties.http://www.mdpi.com/2072-666X/7/12/224microfluidic devicepneumatic microvalveinclined lithographycell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maho Kaminaga Tadashi Ishida Toru Omata |
spellingShingle |
Maho Kaminaga Tadashi Ishida Toru Omata Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography Micromachines microfluidic device pneumatic microvalve inclined lithography cell |
author_facet |
Maho Kaminaga Tadashi Ishida Toru Omata |
author_sort |
Maho Kaminaga |
title |
Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography |
title_short |
Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography |
title_full |
Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography |
title_fullStr |
Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography |
title_full_unstemmed |
Fabrication of Pneumatic Microvalve for Tall Microchannel Using Inclined Lithography |
title_sort |
fabrication of pneumatic microvalve for tall microchannel using inclined lithography |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2016-12-01 |
description |
We used inclined lithography to fabricate a pneumatic microvalve for tall microchannels such as those used to convey large cells. The pneumatic microvalve consists of three layers. The upper layer is the actual liquid microchannel, which has a parallelogram-shaped cross section of width 500 μm, height 100 μm, and an acute angle of 53.6°. The lower layer is a pneumatic microchannel that functions as an actuator, and the middle layer is a thin polydimethylsiloxane membrane between the upper and lower layers. The operation of the pneumatic microchannel actuator causes the thin membrane to bend, resulting in the bending of the liquid microchannel and its closure. It was confirmed that the closure of the liquid microchannel completely stopped the flow of the HeLa cell suspension that was used to demonstrate the operation of the microvalve. The HeLa cells that passed through the microchannel were also observed to retain their proliferation and morphological properties. |
topic |
microfluidic device pneumatic microvalve inclined lithography cell |
url |
http://www.mdpi.com/2072-666X/7/12/224 |
work_keys_str_mv |
AT mahokaminaga fabricationofpneumaticmicrovalvefortallmicrochannelusinginclinedlithography AT tadashiishida fabricationofpneumaticmicrovalvefortallmicrochannelusinginclinedlithography AT toruomata fabricationofpneumaticmicrovalvefortallmicrochannelusinginclinedlithography |
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