Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy

Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy

Significant opportunities remain for pharmacologically enhancing the clinical effectiveness of proton and carbon ion-based radiotherapies to achieve both tumor cell radiosensitization and normal tissue radioprotection. We investigated whether pretreatment with the hydroxamate-based histone deacetyla...

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Bibliographic Details
Main Authors: Alicia M. Johnson, Paula V. Bennett, Katherine Z. Sanidad, Anthony Hoang, James H. Jardine, Deborah J. Keszenman, Paul F. Wilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
HDAC inhibitor
SAHA
radiosensitization
double-strand break
ionizing radiation
protons
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.735940/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.735940/full

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