CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant

CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant

Abstract Background We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients. Methods Forty-nine patients were genotyped for CYP3A5, ABCB1 and SXR polymorphisms and evaluated with tacrolimus thr...

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Bibliographic Details
Main Authors: Stefano Turolo, Alberto Edefonti, Luciana Ghio, Sara Testa, William Morello, Giovanni Montini
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Pediatrics
Subjects:
Kidney transplantation
Acute rejection
SXR
CYP
Tacrolimus
Pharmacogenomics
Online Access:http://link.springer.com/article/10.1186/s12887-020-02152-3

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http://link.springer.com/article/10.1186/s12887-020-02152-3

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