Transmission genetics of drug-resistant hepatitis C virus

Transmission genetics of drug-resistant hepatitis C virus

Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A protease, NS5A phosphoprotein and NS5B polymerase....

Full description

Bibliographic Details
Main Authors: Nicholas van Buuren, Timothy L Tellinghuisen, Christopher D Richardson, Karla Kirkegaard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
hepatitis C virus
drug resistance
antiviral drugs
viral evolution
RNA replication
Online Access:https://elifesciences.org/articles/32579

Internet

https://elifesciences.org/articles/32579

Similar Items