miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.

Bibliographic Details
Main Authors: Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13587-3

Internet

https://doi.org/10.1038/s41467-019-13587-3

Similar Items