miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.

Bibliographic Details
Main Authors: Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13587-3
id doaj-224be2193f454379b9efe6527272f625
record_format Article
spelling doaj-224be2193f454379b9efe6527272f6252021-05-11T11:48:37ZengNature Publishing GroupNature Communications2041-17232019-12-0110111510.1038/s41467-019-13587-3miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetesMartin G. Scherm0Isabelle Serr1Adam M. Zahm2Jonathan Schug3Saverio Bellusci4Rossella Manfredini5Victoria K. Salb6Katharina Gerlach7Benno Weigmann8Anette-Gabriele Ziegler9Klaus H. Kaestner10Carolin Daniel11Institute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenInstitute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of PennsylvaniaDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of PennsylvaniaGerman Center for Lung Research, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung CenterCenter for Regenerative Medicine, University of Modena and Reggio EmiliaInstitute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenDepartment of Medicine 1, University of Erlangen-NurembergDepartment of Medicine 1, University of Erlangen-NurembergInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental HealthDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of PennsylvaniaInstitute of Diabetes Research, Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum MünchenmiRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.https://doi.org/10.1038/s41467-019-13587-3
collection DOAJ
language English
format Article
sources DOAJ
author Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
spellingShingle Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Nature Communications
author_facet Martin G. Scherm
Isabelle Serr
Adam M. Zahm
Jonathan Schug
Saverio Bellusci
Rossella Manfredini
Victoria K. Salb
Katharina Gerlach
Benno Weigmann
Anette-Gabriele Ziegler
Klaus H. Kaestner
Carolin Daniel
author_sort Martin G. Scherm
title miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_short miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_full miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_fullStr miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_full_unstemmed miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
title_sort mirna142-3p targets tet2 and impairs treg differentiation and stability in models of type 1 diabetes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
url https://doi.org/10.1038/s41467-019-13587-3
work_keys_str_mv AT martingscherm mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT isabelleserr mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT adammzahm mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT jonathanschug mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT saveriobellusci mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT rossellamanfredini mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT victoriaksalb mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT katharinagerlach mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT bennoweigmann mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT anettegabrieleziegler mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT klaushkaestner mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
AT carolindaniel mirna1423ptargetstet2andimpairstregdifferentiationandstabilityinmodelsoftype1diabetes
_version_ 1714591539870564352

Similar Items