Novel G1481V and Q1491H SCN5A Mutations Linked to Long QT Syndrome Destabilize the Nav1.5 Inactivation State

Novel G1481V and Q1491H SCN5A Mutations Linked to Long QT Syndrome Destabilize the Nav1.5 Inactivation State

Background: Nav1.5, which is encoded by the SCN5A gene, is the predominant voltage-gated Na+ channel in the heart. Several mutations of this gene have been identified and reported to be involved in several cardiac rhythm disorders, including type 3 long QT interval syndrome, that can cause sudden ca...

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Main Authors: Quentin Plumereau, MSc, Olivier Theriault, PhD, Valérie Pouliot, BSc, Adrien Moreau, PhD, Elodie Morel, PhD, Véronique Fressart, MD, PhD, Isabelle Denjoy, MD, Antoine Delinière, MD, Francis Bessière, MD, Philippe Chevalier, MD, Tamer M. Gamal El-Din, PhD, Mohamed Chahine, PhD
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:CJC Open
Online Access:http://www.sciencedirect.com/science/article/pii/S2589790X20301578

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http://www.sciencedirect.com/science/article/pii/S2589790X20301578

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