Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell–Mediated Mechanism

Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell–Mediated Mechanism

Summary: Human dendritic cells were differentiated from blood monocytes and treated with malondialdehyde (MDA) conjugated with human serum albumin (HSA). Autologous T cells from human plaques or blood were co-cultured with the pre-treated dendritic cells or treated directly. MDA modifications were s...

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Bibliographic Details
Main Authors: Mizanur Rahman, PhD, Johnny Steuer, MD, PhD, Peter Gillgren, MD, PhD, Ákos Végvári, PhD, Anquan Liu, MD, PhD, Johan Frostegård, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19300853

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http://www.sciencedirect.com/science/article/pii/S2452302X19300853

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