A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection

Humanized mouse model generated by grafting primary human hepatocytes (PHHs) to immunodeficient mouse has contributed invaluably to understanding the pathogenesis of hepatitis B virus (HBV). However, the source of PHHs is limited, which necessitates the search for alternatives. Recently, hepatocyte-...

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Bibliographic Details
Main Authors: Lunzhi Yuan, Xuan Liu, Liang Zhang, Xiaoling Li, Yali Zhang, Kun Wu, Yao Chen, Jiali Cao, Wangheng Hou, Jun Zhang, Hua Zhu, Quan Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
stem cells
hepatocyte-like cells
liver humanized mouse
hepatitis B virus
infectious animal model
hHLC-FRGS
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00908/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00908/full

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