Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha.
The transcription of individual genes is determined by combinatorial interactions between DNA-binding transcription factors. The current challenge is to understand how such combinatorial interactions regulate broad genetic programs that underlie cellular functions and disease. The transcription fact...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2877749?pdf=render |