Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.

Bibliographic Details
Main Authors: Sheena Dass, Serena Shunmugam, Laurence Berry, Christophe-Sebastien Arnold, Nicholas J. Katris, Samuel Duley, Fabien Pierrel, Marie-France Cesbron-Delauw, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22956-w
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spelling doaj-226664588bd840de98c6c9d52b6e40252021-05-23T11:12:39ZengNature Publishing GroupNature Communications2041-17232021-05-0112111310.1038/s41467-021-22956-wToxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storageSheena Dass0Serena Shunmugam1Laurence Berry2Christophe-Sebastien Arnold3Nicholas J. Katris4Samuel Duley5Fabien Pierrel6Marie-France Cesbron-Delauw7Yoshiki Yamaryo-Botté8Cyrille Y. Botté9Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Laboratory of Pathogen Host Interactions, UMR 5235, Université de MontpellierApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Université Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAGApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.https://doi.org/10.1038/s41467-021-22956-w
collection DOAJ
language English
format Article
sources DOAJ
author Sheena Dass
Serena Shunmugam
Laurence Berry
Christophe-Sebastien Arnold
Nicholas J. Katris
Samuel Duley
Fabien Pierrel
Marie-France Cesbron-Delauw
Yoshiki Yamaryo-Botté
Cyrille Y. Botté
spellingShingle Sheena Dass
Serena Shunmugam
Laurence Berry
Christophe-Sebastien Arnold
Nicholas J. Katris
Samuel Duley
Fabien Pierrel
Marie-France Cesbron-Delauw
Yoshiki Yamaryo-Botté
Cyrille Y. Botté
Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Nature Communications
author_facet Sheena Dass
Serena Shunmugam
Laurence Berry
Christophe-Sebastien Arnold
Nicholas J. Katris
Samuel Duley
Fabien Pierrel
Marie-France Cesbron-Delauw
Yoshiki Yamaryo-Botté
Cyrille Y. Botté
author_sort Sheena Dass
title Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_short Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_full Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_fullStr Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_full_unstemmed Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
title_sort toxoplasma lipin is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.
url https://doi.org/10.1038/s41467-021-22956-w
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