NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

Nuclear receptor 4A1 (NR4A1, Nur77, TR3) is more highly expressed in breast and solid tumors compared to non-tumor tissues and is a pro-oncogenic factor in solid tumor-derived cancers. NR4A1 regulates cancer cell growth, survival, migration, and invasion, and bis-indole-derived compounds (CDIMs) tha...

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Bibliographic Details
Main Authors: Keshav Karki, Kumaravel Mohankumar, Abigail Schoeller, Gregory Martin, Rupesh Shrestha, Stephen Safe
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
NR4A1
breast cancer
ligands
inhibition
Online Access:https://www.mdpi.com/2072-6694/13/11/2682

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