Induced B Cell Development in Adult Mice

Induced B Cell Development in Adult Mice

We employed the B-Indu-Rag1 model in which the coding exon of recombination-activating gene 1 (Rag1) is inactivated by inversion. It is flanked by inverted loxP sites. Accordingly, B cell development is stopped at the pro/pre B-I cell precursor stage. A B cell-specific Cre recombinase fused to a mut...

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Bibliographic Details
Main Authors: Anne-Margarete Brennecke, Sandra Düber, Bishnudeo Roy, Irene Thomsen, Annette I. Garbe, Frank Klawonn, Oliver Pabst, Karsten Kretschmer, Siegfried Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
bone marrow
RAG
B cell development
B-2/B-1a/B-1b
antibodies
CSR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02483/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02483/full

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