Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling

Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling

Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up Ca2+ from the cytoplasm to maintain the balance of intracellular Ca2+. A decline in expression or activity of SERCA results in persistent store-operated calcium entry (SOCE). In cardiomyocytes as well as vascular smooth muscle cells (SMCs...

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Bibliographic Details
Main Authors: Bo Liu, Dong Wang, Erfei Luo, Jiantong Hou, Yong Qiao, Gaoliang Yan, Qingjie Wang, Chengchun Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
serotonylation
TG2
SERCA2
pulmonary venous smooth muscle cell
store-operated calcium entry
[Ca2+]i
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01611/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01611/full

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