The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.

The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.

The pan-protein kinase C (PKC) inhibitor sotrastaurin (AEB071) is a novel immunosuppressant currently in phase II trials for immunosuppression after solid organ transplantation. Besides T-cell activation, PKC affects numerous cellular processes that are potentially important for the replication of h...

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Bibliographic Details
Main Authors: Thomas von Hahn, Andreas Schulze, Ivan Chicano Wust, Benjamin Heidrich, Thomas Becker, Eike Steinmann, Fabian A Helfritz, Katrin Rohrmann, Stephan Urban, Michael P Manns, Thomas Pietschmann, Sandra Ciesek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3164709?pdf=render

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http://europepmc.org/articles/PMC3164709?pdf=render

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