Age-dependent modifications of AMPA receptor subunit expression levels and related cognitive effects in 3xTg-AD mice

Age-dependent modifications of AMPA receptor subunit expression levels and related cognitive effects in 3xTg-AD mice

GluA1, GluA2, GluA3, and GluA4 are the constitutive subunits of AMPA receptors (AMPARs), the major mediators of fast excitatory transmission in the mammalian central nervous system. Most AMPARs are Ca2+-impermeable because of the presence of the GluA2 subunit. GluA2 mRNA undergoes an editing proce...

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Bibliographic Details
Main Authors: Pamela eCantanelli, Samantha eSperduti, Domenico eCiavardelli, Liborio eStuppia, Valentina eGatta, Stefano Luca Sensi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Gene Expression
Hippocampus
RNA Editing
AMPA receptors
neurotransmission
3xTG-AD mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00200/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00200/full

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