A genome-wide positioning systems network algorithm for in silico drug repurposing
Identification of disease modules in the human interactome can guide more efficacious therapeutic selections. Here, the authors introduce a network-based methodology to identify individualized disease modules by mapping patients’ DNA and RNA sequencing profiles to the interactome, enabling predictio...
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Bibliographic Details
Main Authors: |
Feixiong Cheng,
Weiqiang Lu,
Chuang Liu,
Jiansong Fang,
Yuan Hou,
Diane E. Handy,
Ruisheng Wang,
Yuzheng Zhao,
Yi Yang,
Jin Huang,
David E. Hill,
Marc Vidal,
Charis Eng,
Joseph Loscalzo |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-10744-6
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