A genome-wide positioning systems network algorithm for in silico drug repurposing
Identification of disease modules in the human interactome can guide more efficacious therapeutic selections. Here, the authors introduce a network-based methodology to identify individualized disease modules by mapping patients’ DNA and RNA sequencing profiles to the interactome, enabling predictio...
Main Authors: | Feixiong Cheng, Weiqiang Lu, Chuang Liu, Jiansong Fang, Yuan Hou, Diane E. Handy, Ruisheng Wang, Yuzheng Zhao, Yi Yang, Jin Huang, David E. Hill, Marc Vidal, Charis Eng, Joseph Loscalzo |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10744-6 |
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