Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells

Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells

Glioblastomas (GBM) are very aggressive and malignant brain tumors, with frequent relapses despite an appropriate treatment combining surgery, chemotherapy and radiotherapy. In GBM, hypoxia is a characteristic feature and activation of Hypoxia Inducible Factors (HIF-1α and HIF-2α) has been associate...

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Bibliographic Details
Main Authors: Julie Sesen, Anne Cammas, Sarah J. Scotland, Bertand Elefterion, Anthony Lemarié, Stefania Millevoi, Lijoy K. Mathew, Cathy Seva, Christine Toulas, Elizabeth Cohen-Jonathan Moyal, Nicolas Skuli
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
glioma
glioblastoma
proliferation
apoptosis
eukaryotic translation initiation factor
Int6
eIF3e
Hypoxia Inducible Factors
HIF-1α
HIF-2α
Online Access:http://www.mdpi.com/1422-0067/15/2/2172

Internet

http://www.mdpi.com/1422-0067/15/2/2172

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