The Inflammatory Cytokine IL-3 Hampers Cardioprotection Mediated by Endothelial Cell-Derived Extracellular Vesicles Possibly via Their Protein Cargo

The Inflammatory Cytokine IL-3 Hampers Cardioprotection Mediated by Endothelial Cell-Derived Extracellular Vesicles Possibly via Their Protein Cargo

The biological relevance of extracellular vesicles (EV) released in an ischemia/reperfusion setting is still unclear. We hypothesized that the inflammatory microenvironment prevents cardioprotection mediated by endothelial cell (EC)-derived extracellular vesicles. The effects of naïve EC-derived EV...

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Bibliographic Details
Main Authors: Claudia Penna, Saveria Femminò, Marta Tapparo, Tatiana Lopatina, Kari Espolin Fladmark, Francesco Ravera, Stefano Comità, Giuseppe Alloatti, Ilaria Giusti, Vincenza Dolo, Giovanni Camussi, Pasquale Pagliaro, Maria Felice Brizzi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
cardiac damage
ischemia/reperfusion injury
endothelial-derived extracellular vesicles
inflammatory cytokines
interleukin 3
Online Access:https://www.mdpi.com/2073-4409/10/1/13

Internet

https://www.mdpi.com/2073-4409/10/1/13

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