Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells

Aggrecanases from the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family are important therapeutic targets due to their essential role in aggrecan depletion in arthritic diseases. Whether their function is also important for matrix rearrangements during chondrogenesis and...

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Bibliographic Details
Main Authors: W Richter, B Moradi, CB Little, J Fischer, S Boeuf, F Graf
Format: Article
Language:English
Published: AO Research Institute Davos 2012-05-01
Series:European Cells & Materials
Subjects:
Mesenchymal stem cells
regenerative medicine
aggrecanase
proteoglycan depletion
aggrecan neoepitopes
cartilage development
inflammation
interleukin 1 β
Online Access:http://www.ecmjournal.org/journal/papers/vol023/pdf/v023a25.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol023/pdf/v023a25.pdf

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