Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity.

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity.

Protein arginine methyltransferase 5 (PRMT5) plays critical roles in a wide variety of biological processes, including tumorigenesis. By screening a library of small chemical compounds, we identified eight compounds that selectively inhibit the PRMT5 enzymatic activity, with IC50 values ranging from...

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Bibliographic Details
Main Authors: Gui-Mei Kong, Min Yu, Zhongping Gu, Zhi Chen, Rui-Ming Xu, Deon O'Bryant, Zhengxin Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5555576?pdf=render

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http://europepmc.org/articles/PMC5555576?pdf=render

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