CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies

Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are less susceptible to CAR therapies and instead hav...

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Bibliographic Details
Main Authors: Hannah M. Knochelmann, Aubrey S. Smith, Connor J. Dwyer, Megan M. Wyatt, Shikhar Mehrotra, Chrystal M. Paulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
T cell
solid tumor
adoptive cell transfer
checkpoint
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01740/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01740/full

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