No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly

<p>Abstract</p> <p>Background</p> <p>It has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues that are directly involved in protein function. In agreement with this hypothesis, recent work has show...

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Bibliographic Details
Main Authors: Koonin Eugene V, Wolf Yuri I, Jordan I King
Format: Article
Language:English
Published: BMC 2003-01-01
Series:BMC Evolutionary Biology
Online Access:http://www.biomedcentral.com/1471-2148/3/1