Random migration and signal integration promote rapid and robust T cell recruitment.

Random migration and signal integration promote rapid and robust T cell recruitment.

To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search within each LN. Here we combine simulations and exper...

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Bibliographic Details
Main Authors: Johannes Textor, Sarah E Henrickson, Judith N Mandl, Ulrich H von Andrian, Jürgen Westermann, Rob J de Boer, Joost B Beltman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25102014/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25102014/?tool=EBI

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