Soluble Aβ aggregates can inhibit prion propagation

Soluble Aβ aggregates can inhibit prion propagation

Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrPC). Ligands that bind to PrPC can inhibit prion propagation and neurotoxicity. Extensive prior work established that certain...

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Bibliographic Details
Main Authors: Claire J. Sarell, Emma Quarterman, Daniel C.-M. Yip, Cassandra Terry, Andrew J. Nicoll, Jonathan D. F. Wadsworth, Mark A. Farrow, Dominic M. Walsh, John Collinge
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
amyloid β-protein
alzheimer's disease
automated scrapie cell assay
creutzfeldt–jakob disease
prion
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170158

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170158

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