Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme

Abstract Background The standard first- and second- line chemotherapy backbone regimens for metastatic colorectal cancer (mCRC) are 5-fluorouracil (5-FU)/capecitabine-based with addition of irinotecan or oxaliplatin. Until recently, evidence for optimal sequencing post second-line was sparse. Triflu...

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Bibliographic Details
Main Authors: Timothy Iveson, Angela M. Carter, Kai-Keen Shiu, Clare Spooner, Daniel Stevens, Saifee Mullamitha
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-020-6577-1