Prolonged mechanical ventilation induces cell cycle arrest in newborn rat lung.

Prolonged mechanical ventilation induces cell cycle arrest in newborn rat lung.

RATIONALE: The molecular mechanism(s) by which mechanical ventilation disrupts alveolar development, a hallmark of bronchopulmonary dysplasia, is unknown. OBJECTIVE: To determine the effect of 24 h of mechanical ventilation on lung cell cycle regulators, cell proliferation and alveolar formation in...

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Bibliographic Details
Main Authors: Andreas A Kroon, Jinxia Wang, Brian P Kavanagh, Zhen Huang, Maciej Kuliszewski, Johannes B van Goudoever, Martin Post
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3040197?pdf=render

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http://europepmc.org/articles/PMC3040197?pdf=render

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