The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

The cholesterol-dependent cytolysins (CDCs) are the archetype for the superfamily of oligomeric pore-forming proteins that includes the membrane attack complex/perforin (MACPF) family of immune defense proteins and the stonefish venom toxins (SNTX). The CDC/MACPF/SNTX family exhibits a common protei...

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Bibliographic Details
Main Authors: Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
cold denaturation
complement
gasdermin
perforin
water network
Online Access:https://doi.org/10.1128/mBio.00538-19

Internet

https://doi.org/10.1128/mBio.00538-19

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