Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells

Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells

Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the granules of cytotoxic cells, and have predominantly been studied for their pro-apopt...

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Bibliographic Details
Main Authors: Shuang Li, Christian G. M. van Dijk, Jan Meeldijk, Helena M. Kok, Isabelle Blommestein, Annick L. F. Verbakel, Marit Kotte, Roel Broekhuizen, Miangela M. Laclé, Roel Goldschmeding, Caroline Cheng, Niels Bovenschen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
angiogenesis
endothelium
soluble VEGFR1
granzyme K
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.681967/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.681967/full

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