Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress

Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress

Lung cancer represents an extremely diffused neoplastic disorder with different histological/molecular features. Among the different lung tumors, non-small-cell lung cancer (NSCLC) is the most represented histotype, characterized by various molecular markers, including the expression/overexpression...

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Bibliographic Details
Main Authors: Arianna Giacomini, Sara Taranto, Sara Rezzola, Sara Matarazzo, Elisabetta Grillo, Mattia Bugatti, Alessia Scotuzzi, Jessica Guerra, Martina Di Trani, Marco Presta, Roberto Ronca
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
FGFR1
FGF
fibroblast growth factor
lung cancer
FGF trap
tyrosine kinase inhibitor
Online Access:https://www.mdpi.com/1422-0067/21/24/9376

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https://www.mdpi.com/1422-0067/21/24/9376

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