Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway

Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway

Insulin resistance (IR), caused by impaired insulin signal and decreased insulin sensitivity, is generally responsible for the pathophysiology of type 2 diabetes mellitus (T2DM). Sesquiterpene glycosides (SGs), the exclusive natural products from loquat leaf, have been regarded as potential lead com...

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Bibliographic Details
Main Authors: Jiawei Li, Xiaoqin Ding, Tunyu Jian, Han Lü, Lei Zhao, Jing Li, Yan Liu, Bingru Ren, Jian Chen
Format: Article
Language:English
Published: PeerJ Inc. 2020-11-01
Series:PeerJ
Subjects:
Loquat leaf
Sesquiterpene glycosides
Insulin resistance
HepG2 cells
AMPK
Online Access:https://peerj.com/articles/10413.pdf

Internet

https://peerj.com/articles/10413.pdf

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