Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

The relationship between acidosis within the tumor microenvironment and radioresistance of hypoxic tumor cells remains unclear. Previously we reported that hypoxia-induced carbonic anhydrases CAIX and CAXII constitute a robust pHi-regulating system that confers a survival advantage on hypoxic human...

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Bibliographic Details
Main Authors: Jérôme eDoyen, Scott Kenneth Parks, Serge eMarcié, Jacques ePouysségur, Johanna eChiche
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Oncology
Subjects:
Carbonic Anhydrases
Tumor growth
hypoxia
intracellular pH
Ionizing radiation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00199/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00199/full

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